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$404.94 Total


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“Since taking Holoimmune within 3 days I noticed a difference in energy. It was very dramatic with cognitive clarity and noticed less reactions to food as well. I had some prior issues with environmental poisoning (mold) and I really think my gut immune was very confused even after i cleaned my gut up. All I can say is thank you for such a thoughtful product.”

Pete M. Verified Buyer * Results atypical, Individual results will vary

36+ Studies Back This Gut-Immune ParaProbiotic for Better Health…

  • Supports upper respiratory immune health year round*
  • Aids in Skin-Immune reactions and oral gum health*
  • May Balance under-active or overactive immune systems*
  • May Increase SIgA, a strong protector of gut-immunity*
  • Supports stress and age related decline in immune function*
  • Activates special pDC cells, the leaders of the immune system*
  • Non-Gmo, Vegan, 3 clinically studied strains, No refrigeration

We want a smarter, more balanced immune system. With up to 80% of immune cells in our gut, it is the main place for us to train the immune system.

Heat Killed Probiotics are a breakthrough technology also known as Paraprobiotics. Researchers found that these special strains offered promising immune system benefits including better function and balance. Now you can get all 3 in the same small easy to swallow capsule.

Studies of HoloImmune’s ingredients show support of: 

  • Balanced Environmental Allergen Response*
  • Relief of Skin issues*
  • Year round immune health* 
  • Immune system during stressful times*
  • Oral gum health*
  • Better quality of life*   
  • Improved exercise performance*
  • Gut-immune health*

Here’s What Our Early Testers Are Saying:

“I feel amazing! I feel like it was the missing piece. I’ve been taking HCL, Holo, & TriX for 2 months and was feeling better, but since taking HoloImmune, I have not bloated once. It has increased my food freedom. Cleared a sinus issue coming on in just 2 days. Can’t wait to order more!” – Tester 1

“I have had less fatigue and a lot more good days than I had without HoloImmune, plus a chronic skin issue seems to be clearing.” – Kim

“I have been having skin rashes for a long time and have tried everything. Holoimmune has resolved the rashes on my skin and has given me more energy. My son has started taking it as well and he hasn’t been as rashy or itchy. It’s amazing!” – Lauren

“I have noticed clearer skin since starting HoloImmune” – Emily

“I am perimenopause and guaranteed a breakout prior to my period, that did not happen this month and I am pleasantly surprised. We also recently got sick and I started taking HoloImmune right after. While I recovered within 3-days, my boyfriend, who did not take HoloImmune, his symptoms lingered for 2-weeks.” –  Necia

“Since I’ve added HoloImmune to my daily regimen, I feel stronger than ever. All 3 of my kids were ill and I stayed symptom free with the support of this product!” – Kristina

Adaptogenic Immune Support: healthy responses to the Right things and not the Wrong things

Your immune system has two sides: the adaptive and the innate.

If a feather’s touch will do the job we don’t want our immune system to use a hammer.  And when it’s hammer time (pun intended) we want our body to hit the intended target.  

It then needs to talk to your adaptive immune system about what it found and what needs to happen now and in the future.

Your adaptive immune system is slower but much more targeted, powerful, and has memory.

Together they form a wide-spread and targeted approach to protecting you.  

However, because the system of protecting you is so complex it means there’s 5 common ways it can malfunction.

5 Common Ways the Immune System Malfunctions

At the end of the day we don’t just want a strong immune system we actually want a smart one.  We want an immune system that is attuned to our environment and not at war with it.  

In other words, we want the immune system to have the appropriate responses to the current environment.  We don’t want it to use any extra effort or accidentally attack our own cells.

Here’s 5 common malfunctions:

  1. Under-Active Innate Immunity (too passive)
  2. Overactive Innate Immunity (too aggressive)
  3. Poor Communication between Innate and Adaptive immune systems (disorganized)
  4. Under-Active Adaptive Immunity (not smart enough)
  5. Overactive Adaptive Immunity (too destructive)

Any one of these 5 patterns can get triggered when we get stressed, life changes, or as we age.  To make matters more confusing, sometimes more than one pattern is happening at the same time. 

Which is why taking an adaptogenic immune support product can be so helpful.  Adaptogenic paraprobiotics can help tune up or tune down the patterns that will guide us into more balance. 

In the end we want a healthy immune system that creates a measured response that is not too harsh or too light. 

Combined HoloImmune’s 4 unique ingredients help regulate these 5 immune pathways

After reading the research it became clear there were gut-immune pathways that could be trained by paraprobitics and prebiotics.  And that these pathways could help tune my immune system to be smarter and more balanced. 

While conventional immune support (zinc or vitamin C) provides the raw materials for the body. I wanted a more comprehensive support product that would empower the immune system to make decisions about when and how to mobilize responses to our environment.  

I hand picked each of these amazing ingredients to work synergistically.

Introducing the amazing ingredients in HoloImmune™

Immuse ® is heat-killed Lactococcus lactis JCM 5805, a probiotic backed by 25+ studies and shown to uniquely support a rare type of immune leader called plasmacytoid dendritic cells (pDC’s).  These pDC’s are capable of helping the cross-talk between innate and adaptive immune systems.  Not only that but through their unique leadership position they can support stronger Natural Killer cells.

Immuno-LP20 ® is heat-killed Lactobacillus plantarum L-137 an immunobiotic backed by over 12 years of research. In studies it supports the balancing of Th1 cells and Th2 cells inside the adaptive immune system.  Human studies on Immuno-LP20 ® show support beyond the immune system into oral health and general well-being. 

Lactobacillus acidophilus strain L-92™ is a heat killed probiotic strain that has origins that research started on in 1985. In several human studies L-92 shows support for helping to regulate Th1 and Th2 cells inside the adaptive immune system.  Human studies also show support for lowering parts of an overreactive innate immune system due to environmental allergens.  

Beta Glucans 1,3/1,6 from yeast has been studied extensively in humans and is shown to do many things.  It was chosen for this formula because it’s been shown to support overall immune health for decades but also because it supports SIgA in the gut which is an important part of the innate immune system. Beyond that studies suggest this prebiotic is also supportive to moods and overall well being.

How to Take HoloImmune

If highly sensitive please start by opening the capsule and sprinkling ¼ of it on your food. 

Most people will have no problem starting with 1 capsule per day. 

You may increase the number of capsules per day if under extra stressors.

Choose the 6-Bottle Package
(Or The Package That’s Right For You) Below…

3 Bottles


One-Time Payment:

+ FREE Shipping*

Best Deal

6 Bottles


One-Time Payment:

+ FREE Shipping*

1 Bottle


One-Time Payment:

+ $9.95 Shipping*

Choose the 6-Bottle Package
(Or The Package That’s Right For You) Below…

Best Deal

6 Bottles


One-Time Payment:

+ FREE Shipping*

3 Bottles


One-Time Payment:

+ FREE Shipping*

1 Bottle


One-Time Payment:

+ $9.95 Shipping*

Frequently Asked Questions

Q1: Who is HoloImmune™ For?

A: HoloImmune™ is for anyone who wants to support their immune system year round.  For anyone who’s wanting extra protection due to uncertainty or fear.  It’s built for someone who wants skin and dental gum support. 

HoloImmune™ may help with athletic performance, work productivity, and may support well-being. 

Testers so far have reported improved energy, mental clarity, and less skin upset.

Q2: What makes HoloImmune™ different from other probiotic products I’ve tried?

A: First it is important to know that these specially cultured probiotic strains were shown to support the immune system after they were heat-killed by researchers (also called a paraprobiotic).

This means you don’t need to worry about survivability or refrigeration.  You can even open the capsule if you’d like.    

Second, each of 3 paraprobiotic strains have human and animal studies showing several methods of supporting the immune system.  

Third, they are combined with beta glucans which have been used for decades in supporting the gut-immune connection. 

This is the first product to ever combine these 4 ingredients together for synergistic effects.

Q3 – What are the ingredients in HoloImmune™ ?


Q4 – Is there Gluten, Dairy, Soy, Sugar, or GMO’s in HoloImmune™?

A: No. HoloImmune™ does NOT contain any major allergens, zero sugar, zero flow agents, and is GMO free.  It is made with naturally vegetarian and vegan suitable ingredients. 

Q5– When will my order arrive?

A: When you order you will instantly receive an order confirmation email. You can relax then because we are working hard to get your order out the door to you as quickly as possible!

We will ship your order directly to your home or office using a premium mail carrier and you will have it within 5 to 10 business days of placing your order.

Products are shipped from Chicago, IL, USA, and we will send you a shipment notification email with a tracking number as soon as your order ships so that you can track it right to your door.

Q6 – What’s the refund policy?

A: Your order is backed by a 60-day money-back guarantee.

If you don’t like HoloImmune™ for any reason, email, or call us and we’ll start the refund process.

We’ll send you an RMA and shipping label, and as soon as you send us the unopened bottles back, we’ll issue your money back minus the $12.95 refund processing fee.

Q7 – Is it safe to buy online?

A: Buying online is now one of the safest ways to shop! Special SSL Certificates authenticate our identity and encrypt the information of visitors who enter on our site.

This keeps thieves from “snooping” or “grabbing” any exchange between our Web page and another computer. When an SSL Certificate is installed, you can rest assured that the information you send is secured and can’t be viewed by cyber crooks.

You can know this by looking in the upper part of the screen.

Depending on your device you’ll see a padlock icon in the browser’s status bar and the “HTTPS://” prefix in the URL.

These are the signs that a secure handshake is happening between your device and our website. When the handshake is happening as it is now… you are safe.

We use a third-party credit card processor that meets the strictest international standards for data security to manage our credit card payments, so no one ever has access to your credit card information.

We do NOT keep your credit card number on file.

At Healthy Gut, we take this very seriously and are always doing our best to make this the safest and most secure way for you to shop.

Q9 – What is the shelf-life of HoloImmune ?

A: Each bottle is good for 2 years from the date of manufacturing. An order placed today will be good for at least 18-20 months depending on that date.

Q10 – If I live in California, does this fall under Prop65?

A: Read more about California’s Prop65.

Healthy Gut Nutrition’s claims to support digestion come from its ingredients and its ingredient’s respective studies, as well as anecdotal experiences of customers. The products and the claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease.

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

* Results featured on this web site are atypical. As individuals differ, so will results.