16 years experience
10,000,000+ meals saved
60 day guarantee
16 years experience
10,000,000+ meals saved
60 day guarantee
BEST SELLER
16 years experience
10,000,000+ meals saved
60 day guarantee
HoloImmune™
Doctor-trusted
Clinically-Studied Ingredients
"I have had less fatigue and a lot more good days than I had without HoloImmune, plus a chronic skin issue seems to be clearing"
– Kim
As seen in
Real Results, From Real People
74%
Fewer Seasonal Allergy Symptoms
69%
Improved Immune Reslience
49%
Better Mental Clarity
63%
Less Food Sensitivities
*Survey results reflect real world experiences from buyers who completed our post purchase questionnaire.
My Go-To for Staying Healthy
“Holoimmune helps me so much with not getting sick!! I get sick continuously unless I take holoimmune. When I take holoimmune, I feel amazing and healthy!!”
You wash your hands.
You take your vitamins.
And you still get knocked out by every bug your kids bring home.
Your innate immune system needs more than "support"—it needs training. HoloImmune pairs M-Gard®️ beta glucan with three paraprobiotics to prime your immune response at the source: your gut. Beta glucan activates macrophages and NK cells. Paraprobiotics reinforce gut immune signaling and calm over active responses to allergens. Together, they give your body a faster, smarter first line of defense.
Thoughtfully Designed For Maximum Benefits
Here's inner details that make us better than the rest
Think of Immuse®️ as immune leadership training. It targets plasmacytoid dendritic cells (pDCs)—rare coordinator cells that most supplements completely ignore. These cells bridge your innate and adaptive immune systems, helping your body respond appropriately rather than overreact. Backed by 30 published studies, Immuse showed measurable pDC activation and fewer sick days in trials with athletes—in just 13 days. This isn't generic immune support. It's command-level optimization.
L-92®️ teaches your immune system when not to fight. Allergies, skin reactions, food sensitivities—these signal an overreactive Th1/Th2 response, not a weak immune system. L-92 recalibrates this at the source, training gut dendritic cells to reduce unnecessary over reactions. Clinical trials showed improved nasal and skin symptoms in 8 weeks, with measurable drops in bad health markers. Studied since 1985—this is immune discernment, not just immune support.
Immuno-LP20®️ comes from an unlikely source: narezushi, a fermented fish dish that's nourished Southeast Asian communities for centuries. Science now explains why. This strain is unusually rich in lipoteichoic acids—compounds that activate IL-12 and strengthen Th1 immunity, your body's primary defense against viruses. In a 12-week study, people under high stress who took L-137 got sick less often, recovered faster, and needed less medication—with benefits increasing over time. This is a daily driver, not a sick-day supplement.
M-Gard®️ is beta glucan that actually works. Most don't—wrong structure, wrong source, no immune recognition. M-Gard is purified beta-1,3/1,6-glucan from baker's yeast, produced in Norway using a patented process that preserves the branching pattern your immune cells respond to. It triggers "trained immunity" in macrophages and supports secretory IgA in your gut—the shield layer where immune decisions start. 88 published studies. We're not just signaling immune pathways; we're supporting the terrain where immune decisions begin.
Why 65,372+ Trust Healthy Gut
– Emily
– Kristina
– Elizabeth B.
– Kristin P.
– Emily
– Kristina
– Elizabeth B.
– Kristin P.
– Emily
– Kristina
– Elizabeth B.
– Kristin P.
How to Take HoloImmune
Start slow
If highly sensitive please start by opening the capsule and sprinkling ¼ of it on your food.
Regular Dose
Most people will have no problem starting with 1 capsule per day.
Clinically Relevant
You may increase the number of capsules per day if under extra stressors.
The Healthy Gut difference
How HoloImmune delivers real immune balance
Proof that we give a sh*t.
Best Seller
HoloImmune
Total immune game changer
FAQs
HoloImmune™ is for anyone who wants to support their immune system year round. For anyone who’s wanting extra protection due to uncertainty or fear. It’s built for someone who wants skin and dental gum support.
HoloImmune™ may help with athletic performance, work productivity, and may support well-being.
Testers so far have reported improved energy, mental clarity, and less skin upset.
First it is important to know that these specially cultured probiotic strains were shown to support the immune system after they were heat-killed by researchers (also called a paraprobiotic).
This means you don’t need to worry about survivability or refrigeration. You can even open the capsule if you’d like.
Second, each of 3 paraprobiotic strains have human and animal studies showing several methods of supporting the immune system.
Third, they are combined with beta glucans which have been used for decades in supporting the gut-immune connection.
This is the first product to ever combine these 4 ingredients together for synergistic effects.
Holoimmune is comprised of 3 licensed heat killed strains known as paraprobiotics along with beta gluons.
No. HoloImmune™ does NOT contain any major allergens, zero sugar, zero flow agents, and is GMO free. It is made with naturally vegetarian and vegan suitable ingredients.
Still have questions?
Email us at support@healthygut.com
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