16 years experience
Clinician-formulated
60 day guarantee
16 years experience
Clinician-formulated
60 day guarantee
BEST SELLER
HEALTHY GUT HOLOZYME™ DIGESTIVE ENZYMES World's Most Activated Enzymes™ DIETARY SUPPLEMENT 60 CAPSULES
16 years experience
Clinician-formulated
60 day guarantee
| 7M+ servings of HoloZyme doses delivered

HoloZyme™

Doctor-trusted Clinically-Studied
Noticeably smoother digestion with mineral-activated enzymes
Get more from your food to power energy, brain, and immune health
Eat without the after-effects: gas, bloat, fullness, discomfort
Size:
BEST VALUE

We recommend 3-6 months of consistent use to see results.

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"Love this product! I can digest my meals so much better with this enzyme than any other enzymes I've tried."
– Marli

As seen in

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Real Results, From Real People

87%
Experienced less bloating after meals
82%
Noticed reduction in gas
91%
Saw noticeable digestion improvement
84%
Felt it working within an hour
Survey results reflect real world experiences from buyers who completed our post purchase questionnaire.
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These are the best!
“They are the only enzymes that actually work for me, and I’ve tried many others over the years!”

Less gas. Less

bloat. Less regret.

HoloZyme is engineered to work with every meal guaranteed. It fixes 3 complex problems 1) pH window, 2) co-factor availability, 3) triple-class enzyme coverage (pancreatic, brush border, microbiome). When your life demands good digestion – Holozyme will be there to support you. 
Works across a broad pH range (1.7-11.0)
Works across a broad pH range (1.7-11.0)
Macro-to-micro breakdown: sugars, fiber & more
Macro-to-micro breakdown: sugars, fiber & more
No fillers, no allergens, non-GMO
No fillers, no allergens, non-GMO
Backed by 6 pilot clinical studies
Backed by 6 pilot clinical studies

Every enzyme has a purpose.

Here's the role each one plays in your gut:

3D illustration of a capsule releasing colored spheres connected by lines, showing clustered molecules dispersing from a pill

Garlic, onions, beans, and wheat all contain fructans – sugar chains your body literally cannot digest, which ferment in your gut and cause the bloating you've blamed on a "sensitive stomach." Holozyme delivers a clinically studied dose of 200 INU of inulinase. This enzyme breaks fructans apart in your stomach before they ever cause trouble. Your gut isn't broken — it was just missing an important helper.

Beans, lentils, broccoli, and cabbage contain galacto-oligosaccharides — part of the "O" in FODMAP — complex sugars your body has no enzyme to break down, so they pass undigested into your colon where bacteria turn them into gas and misery. Holozyme includes 650 GalU, a clinically studied amount of alpha-galactosidase, which dismantles these sugars in your stomach before fermentation ever begins. Now you can finally eat the fiber-rich foods your gut microbiome is starving for — without paying for it later.

Protein is the most demanding macronutrient on digestion—so when it isn’t broken down efficiently, it can leave you feeling heavy, gassy, and “still full” hours later. Activ-Blend Protease helps break protein into smaller peptides and amino acids, supporting smoother digestion and helping your body access the building blocks it uses for muscle support, tissue maintenance, and everyday immune function.

Rice, potatoes, bread, and pasta are loaded with starches — long carbohydrate chains that need to be broken down into simple sugars before your body can use them for energy. Holozyme combines 20,000 SKB of amylase to chop starches into smaller fragments, plus 20 AG of glucoamylase to finish the job by releasing individual glucose molecules your cells can actually absorb. The result: carbs that fuel you instead of sitting in your gut like a brick.

Healthy fats from avocados, olive oil, nuts, and salmon are essential for hormone production, brain function, and absorbing vitamins A, D, E, and K — but without enough lipase, fat passes through your system undigested, leaving you with that greasy, heavy feeling and robbing you of nutrients you thought you were getting. Holozyme includes 700 FIP of lipase to break fats into fatty acids and glycerol your body can actually absorb. Now the healthy fats you're paying for finally pay you back.

Vegetables, whole grains, and leafy greens lock their nutrients behind tough fiber walls made of xylan — a plant fiber your body cannot break down on its own. Holozyme includes 2,000 XU of xylanase to break apart those cell walls, releasing trapped vitamins, minerals, and antioxidants that would otherwise pass right through you. You're not just eating your vegetables anymore — you're finally unlocking what's inside them.

Think of these as the spark behind the enzymes. They are nature's electron donors, ancient organic compounds that deliver the spark your enzymes need to activate and perform. Think of them as the ignition system for everything else in the formula — without them, you're leaving enzymatic horsepower on the table.

Cluster of colored spheres connected by teal lines to scattered spheres, with a translucent white-and-green capsule releasing tiny pellets.

Get the most out of HoloZyme™

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Regular Use

2 with each meal
2 capsules before bed
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Advanced Use

4 capsules per meal
4 capsules before bed
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Acute Support

6 capsules per meal
6 capsules before bed
Pro tip icon

Pro Tip:

Consistency matters. Enzymes work better when used on a daily basis, especially during heavier meals, stressful times or when eating foods that normally trigger symptoms.

Shop HoloZyme
Timeline

Day 1-3

Meals feel lighter. Less pressure, bloating, "brick stomach."

Week 1-2

More complete breakdown of foods; bowel movements feel more normal and consistent.

Month 1-2

Better nutrient uptake supports energy, thinking, and immune resilience.

Month 5+

Supports long-term digestive ease; users say, "I can eat without the after-effects."

Timeline

Day 1-3

Meals feel lighter. Less pressure, bloating, "brick stomach."

Week 1-2

More complete breakdown of foods; bowel movements feel more normal and consistent.

Month 1-2

Better nutrient uptake supports energy, thinking, and immune resilience.

Month 5+

Supports long-term digestive ease; users say, "I can eat without the after-effects."

Pro tip icon

Pro Tip:

Consistency matters. Enzymes work better when used on a daily basis, especially during heavier meals, stressful times or when eating foods that normally trigger symptoms.

Shop HoloZyme
Winding pink intestine with a white pill and dark blotches suggesting inflammation and a disrupted gut microbiome Winding pink intestine illustration with a white capsule lodged inside and dark patches suggesting unhealthy areas.

The Healthy Gut difference

Comparison table: Healthy Gut features (checkmarks) vs Other Brands (X marks), showing six trust and testing benefits.

How HoloZyme™ delivers real digestive performance.

Proof that we give a sh*t.

Best Seller
HEALTHY GUT HOLOZYME™ DIGESTIVE ENZYMES World's Most Activated Enzymes™ DIETARY SUPPLEMENT 60 CAPSULES

HoloZyme™

742 Reviews

Activated enzymes for easier digestion.

FAQs

HoloZyme is for anyone who wants the digestive and systemic healing of enzymes. It’s for anyone who’s digestion is too fast, to much gas, bloat, loose, or sour. It helps get all the precious nutrients from every food you eat.

It’s for anyone who wants to systematically use enzymes to support immune function and healthy aging.

Anyone into anti-aging ideas and wanting to feel and look their best should consider HoloZyme as it has been shown to support protein, fat, and carbohydrate absorption in the body in healthy levels in 6 pilot studies.

It is especially helpful for anyone who has long standing digestive issues and or pain related complaints.

It starts with the fact that HoloZyme is the most activated enzyme on the market. It was awarded a patent for its specific activation system. This ALONE make it totally different than all the other enzymes on the market.

We’ve tried all the other brands as well and we ended up licensing these patents in order to make the most activated enzyme on the market.

Why does activation matter?

Because each enzyme needs energy to “turn on” or “activate”. This energy comes from what is called a mineral co-factor. See enzymes are deactivated until they are gifted energy to work. HoloZyme includes this energy right in the capsule versus other brands who rely on the body to do the work.

If the body lacks the co-factors to “turn-on” the enzymes it is likely to stay deactivated.

Also our Activ-Blend ™ base enzymes are dual strain and work anywhere in a pH of 1.7 to a pH of 11.0. This allows this to work anywhere in the body unlike traditional pancreatin and many other enzymes who only work in narrow pH ranges.

We include the highest ingredients in enzymes and therefore need less of them.

Because each enzyme needs energy to “turn on” or “activate”. This energy comes from what is called a mineral co-factor. See enzymes are deactivated until they are gifted energy to work. HoloZyme includes this energy right in the capsule versus other brands who rely on the body to do the work.

If the body lacks the co-factors to “turn-on” the enzymes it is likely to stay deactivated.

Also our Activ-Blend ™ base enzymes are dual strain and work anywhere in a pH of 1.7 to a pH of 11.0. This allows this to work anywhere in the body unlike traditional pancreatin and many other enzymes who only work in narrow pH ranges.

We include the highest ingredients in enzymes and therefore need less of them

No. HoloZyme does NOT contain any major allergens, zero sugar, and is GMO free.

Still have questions?

Email us at support@healthygut.com

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HEALTHY GUT HCL GUARD+ • HOLOZYME DIGESTIVE ENZYMES • TRIBUTYRIN-X BIOME BUILDER — Save 10%
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